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  • Title: Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma.
    Author: Sharma SK, Das MR.
    Journal: Indian J Biochem Biophys; 2002 Jun; 39(3):148-54. PubMed ID: 22905384.
    Abstract:
    G protein beta subunit (Gbeta2) is over-expressed in Zajdela ascitic hepatoma (ZAH), a rat ascitic tumour, at mRNA as well as protein levels. Nuclear run-off transcription analysis suggests that the expression of Gbeta2 in ZAH is regulated mainly at transcriptional as well as post-transcriptional levels. Galphai3 is also over-expressed in ZAH. No amplification or any change in the organization of the genes for GBbeta2 or Galphai3 was observed. It is possible that the over-expression of G protein subunits in ZAH could provide proliferative advantage to the cells by virtue of their effects on second messenger systems.
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