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  • Title: Antifouling eunicellin-type diterpenoids from the gorgonian Astrogorgia sp.
    Author: Lai D, Liu D, Deng Z, van Ofwegen L, Proksch P, Lin W.
    Journal: J Nat Prod; 2012 Sep 28; 75(9):1595-602. PubMed ID: 22905736.
    Abstract:
    Twelve new eunicellin-based diterpenoids, astrogorgins B-M (1-12), were isolated from a Chinese gorgonian Astrogorgia sp., together with ophirin, muricellin, astrogorgin, calicophirins A and B, and 14-deacetoxycalicophirin B. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant antifouling activity was observed for 14-deacetoxycalicophirin B against the larval settlement of the barnacle Balanus amphitrite at nontoxic concentrations with an EC(50) = 0.59 μg/mL, while the other analogues were effective within an EC(50) range of 5.14-17.8 μg/mL.
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