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  • Title: Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74.
    Author: Kawahara T, Izumikawa M, Takagi M, Shin-ya K.
    Journal: Org Lett; 2012 Sep 07; 14(17):4434-7. PubMed ID: 22908979.
    Abstract:
    JBIR-129 was isolated as the potent cytotoxic compound, which consists of the 34-membered polyol macrolide skeleton with five sugar moieties. The relative configuration of the aglycone moiety (C7-C27 and C33-C39) was established by the J-based configuration analysis using vicinal (1)H-(1)H (from (1)H NMR and PS-DQF-COSY spectra) and long-range (1)H-(13)C coupling constants (from sge-HETLOC and several J-resolved HMBC spectra) with steric information obtained from ROESY.
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