These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Biology and differentiation of lymphocytes in the classification of lymphomas].
    Author: Mariuzzi G, Di Loreto C, Mariuzzi L.
    Journal: Recenti Prog Med; 1990 Oct; 81(10):621-8. PubMed ID: 2291005.
    Abstract:
    The classifications of non-Hodgkin's lymphomas are briefly discussed and the processes of proliferation and differentiation of B and T lymphocytes are analyzed. The B and T lymphocytes engaged in the immune response arise from precursor cells through a two-cycle process of proliferation and differentiation: the first cycle produces cells with antigen receptors of varying specificity (resting circulating B and T lymphocytes); the second cycle produces B and T type effector cells and "memory" cells. Each phase of B and T differentiation can give rise to a type of lymphoma; in fact, malignant lymphomas can be divided into categories of precursor B and T cell lymphomas, resting B and T cell lymphomas and activated B and T cell lymphomas. Hodgkin's lymphoma could be considered a lymphoma arising from activated cells with atypical phenotype, i.e. Hodgkin and Reed-Sternberg cells. These cells secrete cytokines which recruit lymphocytes, histiocytes, eosinophils and plasma cells which form the cellular background typical of this tumor.
    [Abstract] [Full Text] [Related] [New Search]