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  • Title: [Zinc-protoporphyrin determination in patients with sideropenic anemia and insufficient erythropoiesis].
    Author: D'Angelo G, Giardini C, Zanco MD.
    Journal: Recenti Prog Med; 1990 Oct; 81(10):658-60. PubMed ID: 2291011.
    Abstract:
    We have measured erythrocyte Zinc-Protoporphyrin and serum ferritin in 125 subjects: 100 seemingly healthy controls, 17 with sideropenic anemia and 8 with erythropoietic insufficiency (sideropenia without anemia). Erythrocyte Zinc-Protoporphyrin was measured using Protofluor Z (Helena--Lab.) and serum ferritin was tested with immunoenzymatic technics. Patients with sideropenic anemia showed erythrocyte Zinc-Protoporphyrin values higher than controls, whereas serum ferritin was significantly lower than controls. Patients with erythropoietic insufficiency also showed erythrocyte Zinc-Protoporphyrin values higher than controls with statistical significance whereas the decrease of serum ferritin was not significant. Our study showed that Zinc-Protoporphyrin, in conjunction with serum ferritin, is a very useful test for evaluation of iron storage.
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