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  • Title: Efavirenz in an obese HIV-infected patient--a report and an in vitro-in vivo extrapolation model indicate risk of underdosing.
    Author: de Roche M, Siccardi M, Stoeckle M, Livio F, Back D, Battegay M, Marzolini C.
    Journal: Antivir Ther; 2012; 17(7):1381-4. PubMed ID: 22910127.
    Abstract:
    Here, we report suboptimal efavirenz exposure in an obese patient treated with the standard 600 mg dose. Tripling the dose allowed attainment of therapeutic efavirenz concentrations. We developed an in vitro-in vivo extrapolation model to quantify dose requirements in obese individuals. Obesity represents a risk factor for antiretroviral therapy underdosing.
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