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  • Title: [The effect of polyamines on lysosome fusion with phagosomes in mouse peritoneal macrophages].
    Author: Mozhenok TP, Bulychev AG, Braun AD.
    Journal: Tsitologiia; 1990; 32(9):882-7. PubMed ID: 2291241.
    Abstract:
    The influence of polyamines on the phagosome-lysosome fusion in murine peritoneal macrophages and on polymerization of G-actin from the rabbit muscle in vitro has been studied. Both natural polyamines (spermin, spermidin, putrescin) and synthetic phenyl derivates of polyamines (3,3'-diaminobensidin, 1,5-naphtalin diamine, 4,4'-diaminodiphenilmetan, dancylcadaverin) were used. Unlike the phenyl derivates of polyamines and putrescin, spermin and spermidin stimulate the phagosome-lysosome fusion to induce G-actin polymerization. Possible mechanisms of action of the above polyamines are discussed.
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