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  • Title: The value of examination of multiple levels of mammary needle core biopsy specimens taken for investigation of lesions other than calcification.
    Author: Lee AH, Villena Salinas NM, Hodi Z, Rakha EA, Ellis IO.
    Journal: J Clin Pathol; 2012 Dec; 65(12):1097-9. PubMed ID: 22918889.
    Abstract:
    AIMS: It is a standard practice to examine multiple levels of needle core biopsies taken for mammographic calcification, but there is almost no evidence on the value of levels in core biopsies taken for other reasons. This study aimed to assess the value of levels for needle core biopsies taken for investigation of lesions other than calcification. A secondary aim was to assess interobserver agreement of diagnosis. METHODS: For each of the 375 breast core biopsies with three levels the first level was reviewed and a diagnosis made. Then levels 2 and 3 were reviewed and a final diagnosis was made. RESULTS: The diagnosis after examining three levels was different from that in the initial level in 4 of 272 (1.5%, 95% CI 0.04% to 3%) core biopsies taken for reasons other than calcification and in 13 of 103 (13%, 95% CI 6% to 19%) biopsies taken for investigation of calcification. Interobserver agreement of the original diagnosis at the time of reporting and the final diagnosis at the review for this study was 96% (κ 0.947). CONCLUSIONS: This study confirms the value of levels of biopsies taken to investigate mammographic calcification, but suggests that routine levels are of limited value for breast core biopsies taken for other reasons.
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