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  • Title: The involvement of microglial cells in Japanese encephalitis infections.
    Author: Thongtan T, Thepparit C, Smith DR.
    Journal: Clin Dev Immunol; 2012; 2012():890586. PubMed ID: 22919405.
    Abstract:
    Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
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