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  • Title: Phorone A and isophorbasone A, sesterterpenoids isolated from the marine sponge Phorbas sp.
    Author: Wang W, Lee Y, Lee TG, Mun B, Giri AG, Lee J, Kim H, Hahn D, Yang I, Chin J, Choi H, Nam SJ, Kang H.
    Journal: Org Lett; 2012 Sep 07; 14(17):4486-9. PubMed ID: 22920512.
    Abstract:
    A chemical investigation of a Korean marine sponge, Phorbas sp., yielded unprecedented sesterterpenoids phorone A (1) and isophorbasone A (2) along with ansellone B (3) and phorbasone A acetate (4). Their complete structures were elucidated by the combination of spectroscopic data and chemical manipulation. Phorone A (1) and isophorbasone A (2) have the new "phorane"(5) and "isophorbasane"(6) sesterterpenoid carbon skeletons, respectively. Ansellone B (3) and phorbasone A acetate (4) exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 LPS-activated mouse macrophage cells with IC(50) values of 4.5 and 2.8 μM, respectively.
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