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  • Title: Total synthesis of incarviditone and incarvilleatone.
    Author: Brown PD, Willis AC, Sherburn MS, Lawrence AL.
    Journal: Org Lett; 2012 Sep 07; 14(17):4537-9. PubMed ID: 22931401.
    Abstract:
    The total synthesis of the racemic natural products (±)-incarviditone and (±)-incarvilleatone has been accomplished in three steps via biomimetic dimerization of (±)-rengyolone. Homochiral dimerization of (±)-rengyolone affords (±)-incarviditone through a domino oxa-Michael/Michael sequence. Heterochiral dimerization, involving a domino oxa-Michael/Michael/aldol reaction sequence, affords (±)-incarvilleatone. Single-crystal X-ray analysis of a derivative of (±)-incarviditone has resulted in revision of the originally proposed structure.
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