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  • Title: [Changes in the sleep-wakefulness cycle in experimental Parkinson's syndrome].
    Author: Shandra AA, Godlevskiĭ LS, Makul'kin RF, Mazarati AM, Lefter'ev RN.
    Journal: Patol Fiziol Eksp Ter; 1990; (5):6-9. PubMed ID: 2293170.
    Abstract:
    It was demonstrated in rat experiments that in modelling the akinetico-rigid parkinsonian syndrome by injecting kainic acid into the caudate nuclei the phases of wakefulness and light slow-wave sleep decreased while the phase of deep slow-wave sleep increased. In the tremorogenic from of the parkinsonian syndrome induced by reserpine the phases of wakefulness and deep slow-wave sleep decreased in the rats while the phases of light slow-wave and paradoxical sleep increased. In destruction of the substantia nigra with kainic acid the phase of paradoxical sleep reduced. The results of the study are discussed from the standpoint of the generator mechanisms of the development of neuropathological syndromes and the mechanisms of the interrelations of parkinsonism and epilepsy.
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