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  • Title: [Effect of electroacupuncture pre-treatment on myocardial enzyme levels in recurrent myocardial ischemia rabbits].
    Author: Huang RL, Han S, Qin LH, Sun ZR.
    Journal: Zhen Ci Yan Jiu; 2012 Jun; 37(3):224-8. PubMed ID: 22934394.
    Abstract:
    OBJECTIVE: To observe the effect of electroacupuncture (EA) preconditioning of "Neiguan" (PC 6) on myocardial enzyme levels in acute recurrent myocardial ischemia rabbits so as to study its mechanisms underlying protection of ischemic myocardium. METHODS: A total of 40 healthy rabbits were randomized into normal control, myocardial ischemia (MI) model, EA preconditioning (EA-P), recurrent MI (RMI), EA-P+ RMI groups. MI model was duplicated by auricular intravenous administration of Posterior Pituitary Injection (PPI, 0.3 mL/kg). EA (2 Hz/70 Hz, 2-4 mA) was applied to bilateral PC 6 for 30 min, once daily for 7 d before MI. The contents of serum aspartate aminotransferase (AST), isoenzymes of creatine kinase (CK-MB), lactate dehydrogenase (LDH), creatine kinase (CK), alpha-hydroxybutyrate dehydrogenase (alpha-HBD) were detected by automatic biochemistry analyzer. RESULTS: Following administration of PPI, ECG-ST(II), serum AST, CK-MB, LDH, CK and alpha-HBD levels were increased significantly in the MI and RMI groups (P<0.01). Compared with the MI model group, ECG-ST(II), serum AST, CK-MB, LDH, CK and alpha-HBD levels were down-regulated considerably in the EA-P group (P<0.01), and ECG-ST(II), serum AST, CK-MB, LDH, CK and alpha-HBD levels were obviously lower in the EA-P+ RMI group than in the RMI group (P<0.01). No significant differences were found between the MI and RMI groups, and between EA-P and EA-P + RMI groups in the above-mentioned 6 indexes (P>0.05). CONCLUSION: Electroacupuncture preconditioning has a remarkable effect in the prevention of ischemic myocardial injury of both acute and recurrent myocardial ischemia in the rabbit, which is closely associated with its functions in lowering serum AST, CK-MB, LDH, CK and alpha-HBD contents.
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