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  • Title: A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold.
    Author: Mulder GE, Kruijtzer JA, Liskamp RM.
    Journal: Chem Commun (Camb); 2012 Oct 14; 48(80):10007-9. PubMed ID: 22935751.
    Abstract:
    We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.
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