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  • Title: Palladium-catalyzed C(sp2)-H cyanation using tertiary amine derived isocyanide as a cyano source.
    Author: Peng J, Zhao J, Hu Z, Liang D, Huang J, Zhu Q.
    Journal: Org Lett; 2012 Sep 21; 14(18):4966-9. PubMed ID: 22937807.
    Abstract:
    An unprecedented palladium-catalyzed cyanation of aromatic C-H bonds by using tertiary amine derived isocyanide as a novel cyano source was developed. Cu(TFA)(2) was used as a requisite stoichiometric oxidant. Mechanistic studies suggest that a tertiary carbon cation-based intermediate is involved following the C-N bond breakage.
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