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  • Title: Label-free detection of DNA hybridization using transistors based on CVD grown graphene.
    Author: Chen TY, Loan PT, Hsu CL, Lee YH, Tse-Wei Wang J, Wei KH, Lin CT, Li LJ.
    Journal: Biosens Bioelectron; 2013 Mar 15; 41():103-9. PubMed ID: 22944023.
    Abstract:
    The high transconductance and low noise of graphene-based field-effect transistors based on large-area monolayer graphene produced by chemical vapor deposition are used for label-free electrical detection of DNA hybridization. The gate materials, buffer concentration and surface condition of graphene have been optimized to achieve the DNA detection sensitivity as low as 1 pM (10(-12) M), which is more sensitive than the existing report based on few-layer graphene. The graphene films obtained using conventional PMMA-assisted transfer technique exhibits PMMA residues, which degrade the sensing performance of graphene. We have demonstrated that the sensing performance of the graphene samples prepared by gold-transfer is largely enhanced (by 125%).
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