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  • Title: Differential effect of insulin like growth factor-I on constriction of human uterine and placental arteries.
    Author: Corcoran JJ, Charnock JC, Martin J, Taggart MJ, Westwood M.
    Journal: J Clin Endocrinol Metab; 2012 Nov; 97(11):E2098-104. PubMed ID: 22948758.
    Abstract:
    CONTEXT: Discrete regulation of the uterine and placental vasculatures is an important feature of uteroplacental perfusion and pregnancy success because appropriate maternal/fetal exchange of nutrients and gases is crucial for normal fetal growth. Placental vasculature lacks autonomic innervation so tone is controlled by locally derived vasoactive factors. IGF-I, which is produced by the placenta, is critical for normal fetal growth and studies of animal vascular systems have shown that IGF-I regulates vasomotor tone. OBJECTIVE: The objective of the study was to determine whether IGF-I directly alters human placental and myometrial arterial tone in vitro. PARTICIPANTS: Women with uncomplicated pregnancy delivering a singleton infant at term participated in the study. SETTING: The study was conducted at university hospital laboratories. MAIN OUTCOME MEASURE(S): Comparison of arterial tension measured before and after exposure to IGF-I. DESIGN: Placental and myometrial arteries were mounted on a wire myograph, exposed to the constrictor U46619 (10(-10) to 10(-5) m), returned to baseline tension, and then incubated with IGF-I (0-500 ng/ml) for various time points before performing a second dose-response curve to U46619. IGF-I receptor protein expression was assessed. RESULTS: IGF-I did not acutely alter the response of placental arteries to U46619. Exposure of myometrial arteries to IGF-I caused a rightward shift of U46619 dose-response curves (P < 0.05); EC(50) data were significantly increased at 30 (15.5 ± 2.8 vs. 133 ± 44 nm, before and after IGF treatment, respectively) and 60 min (10.9 ± 1.9 vs. 146 ± 47 nm). Placental and myometrial arteries had a similar IGF-I receptor expression profile. CONCLUSIONS: IGF-I acutely modulates the vasomotor tone of human myometrial, but not placental, arteries, suggesting that IGF-I regulates the delivery of maternal blood to the placenta.
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