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  • Title: Immune thrombocytopenia in adults: an update.
    Author: Thota S, Kistangari G, Daw H, Spiro T.
    Journal: Cleve Clin J Med; 2012 Sep; 79(9):641-50. PubMed ID: 22949345.
    Abstract:
    Immune thrombocytopenia (ITP) in adults is a chronic disease resulting from increased platelet destruction and impaired platelet production. Splenectomy remains the most effective and durable treatment in cases that are refractory to first-line therapy, but its use has declined because of the availability of alternate medical therapy, the associated risk of infection, and concern for surgery-related complications. Rituximab (Rituxan) may be an effective alternative but carries the risk of immunosuppression.
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