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  • Title: [Tyrosine-alpha-ketoglutarate transaminase activity in the rat liver after partial hepatectomy and CCl4 poisoning].
    Author: Iakobson GS, Sorokin AS, Gizatulin ZIa, Shorin IuP.
    Journal: Vopr Med Khim; 1977; 23(5):701-3. PubMed ID: 22956.
    Abstract:
    Acitivity of tyrosine-alpha-ketoglutarate transaminase and induction of the enzyme by hydro cortisone were studied in rat liver tissue after partial hepatectomy and intoxication with CCl4 Administration of the hormone increased the enzymatic activity within 72 hrs after treatment with CCl4 but did not affect its value within 8 and 24 hrs. Activation of the enzyme by hydrocortisone correlated with the increased enzymatic activity observed within 20 hrs after partial hepatectomy. Possible mechanisms for activation of the enzyme, caused by endo- and exogenous factors, are discussed.
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