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  • Title: Highly enantioselective synthesis of warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts.
    Author: Dong J, Du DM.
    Journal: Org Biomol Chem; 2012 Oct 28; 10(40):8125-31. PubMed ID: 22956019.
    Abstract:
    An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).
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