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  • Title: A label-free real time fluorometric assay for protease and inhibitor screening with a released heme.
    Author: Li W, Chen J, Jiao H, Zhang Q, Zhou H, Yu C.
    Journal: Chem Commun (Camb); 2012 Oct 18; 48(81):10123-5. PubMed ID: 22957343.
    Abstract:
    A label free continuous assay for protease activity and inhibitor screening has been developed. A protease (trypsin) could digest hemoglobin. Free heme molecules were released. Strong π-π stacking and hydrophobic interactions with the perylene probe resulted in efficient quenching of the probe's monomer fluorescence.
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