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  • Title: In vivo evaluation of porous hydroxyapatite/chitosan-alginate composite scaffolds for bone tissue engineering.
    Author: Jin HH, Kim DH, Kim TW, Shin KK, Jung JS, Park HC, Yoon SY.
    Journal: Int J Biol Macromol; 2012 Dec; 51(5):1079-85. PubMed ID: 22959955.
    Abstract:
    Porous hydroxyapatite (HAp)/chitosan-alginate composite scaffolds were prepared through in situ co-precipitation and freeze-drying for bone tissue engineering. The composite scaffolds were highly porous and interconnected with a pore size of around 50-220 μm at low concentrations of HAp. As the HAp content increased, the porosity of the scaffolds decreased from 84.98 to 74.54%. An MTT assay indicates that the obtained scaffolds have no cytotoxic effects on MG-63 cells, and that they have good biocompatibility. An implantation experiment in mouse skulls revealed that the composite scaffold provides a strong positive effect on bone formation in vivo in mice. Furthermore, that HAp/chitosan-alginate composite scaffold has been shown to be more effective for new bone generation than chitosan-alginate scaffold.
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