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  • Title: Monoamine oxidase inhibitors and neuroprotection: a review.
    Author: Al-Nuaimi SK, Mackenzie EM, Baker GB.
    Journal: Am J Ther; 2012 Nov; 19(6):436-48. PubMed ID: 22960850.
    Abstract:
    Monoamine oxidase inhibitors have been available for more than 50 years, initially developed as antidepressants but currently used in a variety of psychiatric and neurological conditions. There has been a recent surge of interest in monoamine oxidase inhibitors because of their reported neuroprotective and/or neurorescue properties. Interestingly, it seems that often these properties are independent of their ability to inhibit monoamine oxidase. This review article presents an overview of the neuroprotective/neurorescue properties of these multifaceted drugs and focuses on phenelzine, (-)-deprenyl, rasagiline, ladostigil, tranylcypromine, moclobemide, and clorgyline and their possible neuroprotective mechanisms.
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