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  • Title: In vivo photoacoustic therapy with cancer-targeted indocyanine green-containing nanoparticles.
    Author: Zhong J, Yang S, Zheng X, Zhou T, Xing D.
    Journal: Nanomedicine (Lond); 2013 Jun; 8(6):903-19. PubMed ID: 22963234.
    Abstract:
    AIM: The objective of this work was to study the photoacoustic effect of a special nanoparticle for selective cancer cell killing both in vitro and in vivo. MATERIALS & METHODS: The nanoparticles (NPs) consisting of indocyanine green (ICG), phospholipid-polyethylene glycol (PL-PEG) and folic acid (FA) were used as cancer-targeting nanoprobes. Cancer cells incubated with the ICG-PL-PEG-FA solution were exposed to laser pulses. Finally, tumors in mice were treated with photoacoustic technique. RESULTS: High selectivity of the photoacoustic destruction of cancer cells was observed. The tumors in mice after photoacoustic treatment showed a much slower growth rate. CONCLUSION: The destruction of the cells was due to the photoacoustic effect originating from the NPs. The ICG-PL-PEG NP-based photoacoustic therapy would be a safe and highly efficient cancer treatment technique.
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