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  • Title: IgG4-related orbital disease: a meta-analysis and review.
    Author: Andrew N, Kearney D, Selva D.
    Journal: Acta Ophthalmol; 2013 Dec; 91(8):694-700. PubMed ID: 22963447.
    Abstract:
    IgG4-related orbital disease (IgG4-ROD) is a recently described condition that may account for a significant proportion of idiopathic lymphoplasmacytic or sclerotic orbital lesions. This study is the first meta-analysis of published cases and reveals several differences between IgG4-related disease affecting the orbit and that affecting the pancreas. IgG4-ROD affects a slightly younger group of patients, affects men and women approximately equally, is commonly associated with salivary gland lesions, is associated with a relatively higher serum IgG4 and may confer an increased risk of non-Hodgkin Lymphoma. Its pathogenesis may involve an immune response to antigen exposure in the upper aerodigestive tract.
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