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  • Title: Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4.
    Author: Bai R, Liu J, Zhu Y, Yang X, Yang C, Kong L, Wang X, Zhang H, Yao H, Shen M, Wu X, Xu J.
    Journal: Bioorg Med Chem Lett; 2012 Oct 15; 22(20):6490-3. PubMed ID: 22963765.
    Abstract:
    (±)-7,8-Dihydroxy-3-methyl-isochromanone-4 [(±)-XJP] is a natural antihypertensive product contained in banana (Musa sapientum L.) peel. (-)-XJP and (+)-XJP were first obtained by chiral resolution, meanwhile circular dichroism (CD) calculations and chiral synthesis were employed to investigate the absolute configuration. The results indicated that the absolute configuration of (+)-XJP is S-configured and the absolute configuration of (-)-XJP is R-configured. Furthermore, the evaluation of antihypertensive effects in vivo proved that R-(-)-XJP was more potent than S-(+)-XJP and [(±)-XJP].
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