These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Genetically encodable design of ligand "bundling" on the surface of nanoparticles.
    Author: Lu Y, Wang J, Wang J, Wang L, Au SW, Xia J.
    Journal: Langmuir; 2012 Oct 02; 28(39):13788-92. PubMed ID: 22967133.
    Abstract:
    Polyhistidine peptide dendrimer self-assembles on CdSe/ZnS quantum dots (QDs) with very high affinity and stability, a property ascribable to its multivalent geometry. Here we designed a fluorescent protein, GCN-mCherry, that exists as an oligomeric bundled structure in solution as well as on the surface to imitate the structure of a synthetic dendrimer. GCN-mCherry forms a very stable assembly with QDs, which can resist displacement by 500 mM imidazole and the dendrimer peptide, as measured by the Förster resonance energy transfer from QD to mCherry. Our work manifested a prominent stability enhancement of protein-nanoparticle assembly through directional ligand-ligand interaction on the surface.
    [Abstract] [Full Text] [Related] [New Search]