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  • Title: Association of three SNPs in interleukin-28B with graft hepatic dysfunction after liver transplantation in Chinese Han population.
    Author: Chen J, Li Y, Wang L, Fu Y, Liao Y, Zhang J.
    Journal: Gene; 2012 Oct 15; 508(1):121-4. PubMed ID: 22967712.
    Abstract:
    BACKGROUND: Recurrent graft infection limited the effect of LT, early recognition and prophylaxis of HBV recurrence are very important, and interleukin 28B (IL‐28B) gene was reported to be associated with HBV infection. AIMS: To explore the association between IL-28B single-nucleotide polymorphisms (SNPs) and graft re-infection after liver transplantation(LT). METHODS: 21 recipients with hepatitis B virus(HBV) recurrence and 157 recipients without HBV recurrence were included. We studied three SNPs in the promoter region of IL-28B gene at the positions rs12979860,rs12980275 and rs8099917 by HRM analysis (high-resolution melting curve analysis). RESULTS: Hepatic allograft dysfunction was more likely to be associated with IL-28B SNPs. However, there was no significant difference in the frequencies of IL-28B gene distribution in recipients with or without HBV recurrence. CONCLUSION: IL-28B gene polymorphism may be associated with the prognosis of LT recipients but it needs more experiments.
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