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  • Title: IgG4-related paratesticular pseudotumor in a patient with autoimmune pancreatitis and retroperitoneal fibrosis: an extrapancreatic manifestation of IgG4-related disease.
    Author: Hart PA, Moyer AM, Yi ES, Hogan MC, Pearson RK, Chari ST.
    Journal: Hum Pathol; 2012 Nov; 43(11):2084-7. PubMed ID: 22974477.
    Abstract:
    In this report, we describe the first case of a patient with an IgG4-related paratesticular pseudotumor. He had histologically proven autoimmune pancreatitis, then later developed a scrotal mass. The orchiectomy specimen revealed that this was a paratesticular pseudotumor with histopathologic and immunohistochemistry findings characteristic of IgG4-related disease. Paratesticular pseudotumors are uncommon causes of intrascrotal masses and have an unexplained pathogenesis. A variety of genitourinary manifestations of IgG4-related disease including IgG4-related tubulointerstitial nephritis, IgG4-related ureteral pseudotumors, and IgG4-related prostatitis has been previously reported. The current case highlights the need to have a high index of suspicion for IgG4-tissue infiltration in patients with known autoimmune pancreatitis, particularly those with a pseudotumor.
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