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  • Title: Protein kinase-C involvement in thymocyte apoptosis induced by hydrocortisone.
    Author: Ojeda F, Guarda MI, Maldonado C, Folch H.
    Journal: Cell Immunol; 1990 Feb; 125(2):535-9. PubMed ID: 2297799.
    Abstract:
    The involvement of protein kinase-C in thymocytes death induced by hydrocortisone was studied. Thymus cells were incubated 6 hr or in the presence of hydrocortisone, labeled with Acridine orange, and the DNA content of each nuclei was estimated by cytofluorimetry. The results indicate that hydrocortisone-induced DNA fragmentation can be prevented by adding the protein kinase-C inhibitor H-7 to the cell suspension. Incubation of the H-A 1004, an inhibitor of c-AMP-dependent protein kinase, with low effect on on protein kinase-C, did not interfere with the cortisone-mediated DNA fragmentation. Therefore, it can be concluded that protein kinase-C plays an important role in the process of lympholysis mediated by corticoids.
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