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  • Title: One-pot synthesis of amides from aldehydes and amines via C-H bond activation.
    Author: Cadoni R, Porcheddu A, Giacomelli G, De Luca L.
    Journal: Org Lett; 2012 Oct 05; 14(19):5014-7. PubMed ID: 22978698.
    Abstract:
    A one-pot synthesis of amides from aldheydes with N-chloroamines, prepared in situ from amines, has been developed. Both aliphatic and aromatic aldehydes and many types of mono- and disubstituted amines are tolerant in this transformation. This cross-coupling reaction appears simple and convenient, has a wide substrate scope and makes use of cheap, abundant, and easily available reagents.
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