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  • Title: Pro-inflammatory cytokine profile of critically ill septic patients following therapeutic plasma exchange.
    Author: Hamishehkar H, Beigmohammadi MT, Abdollahi M, Mousavi S, Ziaie S, Sharifian RA, Davoudi S, Mojtahedzadeh M.
    Journal: Transfus Apher Sci; 2013 Feb; 48(1):75-8. PubMed ID: 22981045.
    Abstract:
    UNLABELLED: Severe sepsis involves a generalized inflammatory response, mediated by a number of various cytokines and factors. Plasma exchange (PE) has been proposed as a therapeutic approach to improve survival of patients with severe sepsis and septic shock. The theory is that removing harmful excessive endogenous inflammatory mediators is beneficial. Upon establishment of a diagnosis of severe sepsis, twelve patients received PE plus conventional sepsis treatment. Interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α were assayed before and after each session of PE. RESULTS: There were no significant changes in cytokine plasma levels after each PE session compared to pre-procedure levels. Among measured pro-inflammatory cytokines, only the plasma levels of IL-6 before the 2nd and 3rd PE sessions were lower than baseline levels (p=0.011 and p=0.012, respectively). All patients tolerated PE therapy well without any adverse effects or homodynamic instability. The results of this study showed that PE does not have a direct and rapid effect on plasma level of TNF-α, IL-1β and IL-6.
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