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  • Title: Haplotypic association of ADAM33 (T+1, S+1 and V - 3) gene variants in genetic susceptibility to asthma in Indian population.
    Author: Tripathi P, Awasthi S, Prasad R, Ganesh S.
    Journal: Ann Hum Biol; 2012; 39(6):479-83. PubMed ID: 22989201.
    Abstract:
    AIM: The aim of this study was to find out if the ADAM33 gene polymorphisms T+1(A>G), S+1(T>A) and V - 3(C>T) and their haplotypes play any role in genetic susceptibility to asthma. SUBJECTS AND METHODS: Three hundred and ninety healthy controls and 386 asthmatic patients from Lucknow, India, were recruited for the study. Subjects were aged between 1-50 years. Among total recruited asthma cases, 95 (24.6%) had mild intermittent asthma, 235 (60.9%) had mild persistent asthma and 56 (14.5%) had moderate persistent asthma. Genotyping was carried out using the Polymerase Chain Reaction and Restriction Fragment Length polymorphism (PCRRFLP) method. RESULTS: No significant differences in the genotype or allele frequencies of ADAM33 gene polymorphisms between asthmatic patients and healthy controls were found [p-value>0.05 (All the p-values were Bonferroni corrected)]. Also, no association of studied SNPs with the severity of the disease asthma was observed. However, the TTA haplotype was observed to be associated with asthma (OR = 3.4; 95%CI = 1.4-8.7; p = 0.002). CONCLUSIONS: SNPs, T+1, S+1 and V - 3 do not individually confer any significant risk of asthma or its severity, but haplotype analysis suggests all three polymorphisms together play an important role in the disease of asthma.
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