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  • Title: Leukotriene C4 elimination and metabolism in man.
    Author: Maltby NH, Taylor GW, Ritter JM, Moore K, Fuller RW, Dollery CT.
    Journal: J Allergy Clin Immunol; 1990 Jan; 85(1 Pt 1):3-9. PubMed ID: 2299103.
    Abstract:
    Three doses of radiolabeled leukotriene C4 (0.2 to 15 muCi) were infused into three subjects to investigate its metabolism and routes of elimination during 4 days. Between 12% and 20% of the infused dose was recovered in the urine within 24 hours, of which a substantial and relatively constant proportion (4.1% to 6.3% total dose) appeared as leukotriene E4 (LTE4), mainly in the first 4 hours. Polar omega-oxidation products, N-acetyl LTE4, and tritiated water were also present. Fecal elimination accounted for a further 30% to 40% of the infused dose. In the absence of altered metabolism or biliary excretion, urinary LTE4 may be a useful measure of whole body production of the cysteinyl leukotrienes.
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