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  • Title: Proteomic profiling of tumor-initiating cells in HT-29 human colorectal cancer cells.
    Author: Lee HN, Park SH, Lee EK, Bernardo R, Kim CW.
    Journal: Biochem Biophys Res Commun; 2012 Oct 12; 427(1):171-7. PubMed ID: 22995320.
    Abstract:
    Recent reports have suggested that tumors are organized in heterogeneous populations. Within these populations, a small subpopulation of cells is more capable of initiating malignancy; these are called cancer stem cells. In this study, HT-29 cells were sorted according to the presence or absence of the cancer stem cell marker CD133. We confirmed that CD133+ cells possessed higher clonogenicity compared to CD133- cells. Furthermore, proteomic analysis identified 10 proteins, including actin-related protein 2/3 complex subunit 5-like and profilin 2. In conclusion, our data demonstrated that the expression of specific proteins associated with metastasis and invasion in CD133+ cells contributed to the stemness and tumorigenic properties of these cells.
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