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  • Title: Increased fecal calprotectin in preterm infants with necrotizing enterocolitis.
    Author: Aydemir G, Cekmez F, Tanju IA, Canpolat FE, Genc FA, Yildirim S, Tunc T, Sarici SU.
    Journal: Clin Lab; 2012; 58(7-8):841-4. PubMed ID: 22997988.
    Abstract:
    BACKGROUND: Necrotizing entrocolitis (NEC) remains a potentially fatal disease in premature infants despite the recent advances in neonatal care. It is a disease with a multifactorial etiology leading to the one common final pathway of necrosis and inflammmation of the neonatal intestine. METHODS: Calprotectin is a calcium and zinc-binding protein in human neutrophils. Its concentration rises in various organic bowel diseases in adults and is resistant to degradation and has been proposed as a useful, simple, and rapid diagnostic method of inflammatory bowel disease that shows gastrointestinal inflammation in children and adults. RESULTS: We found that infants with necrotizing enterocolitis had increased fecal calprotectin concentrations, and there was a correlation between calprotectin concentrations and severity of NEC. CONCLUSIONS: We concluded that fecal calprotectin is a useful marker for diagnosis and severity of NEC in preterm infants.
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