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  • Title: Inactivation of gluconeogenic enzymes in glycolytic mutants of Saccharomyces cerevisiae.
    Author: Gancedo JM, Gancedo C.
    Journal: Eur J Biochem; 1979 Nov; 101(2):455-60. PubMed ID: 230032.
    Abstract:
    Yeast mutants blocked at different steps of the glycolytic pathways have been used to study the inactivation of several gluconeogenic enzymes upon addition of sugars. While phosphorylation of the sugars appears a requisite for the inactivation of fructose 1,6-bisphosphatase and phosphoenol-pyruvate carboxykinase, malate dehydrogenase is inactivated by fructose in mutants lacking hexokinase. The normal inactivation elicited by glucose in a mutant lacking phosphofructokinase indicates that the process does not require metabolism of the sugar beyond hexose monophosphates. A possible role for ATP in the inactivation process is suggested.
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