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  • Title: Length regulation of active biopolymers by molecular motors.
    Author: Johann D, Erlenkämper C, Kruse K.
    Journal: Phys Rev Lett; 2012 Jun 22; 108(25):258103. PubMed ID: 23004664.
    Abstract:
    For biopolymers like cytoskeletal actin filaments and microtubules, assembly and disassembly are inherently dissipative processes. Molecular motors can affect the rates of subunit removal at filament ends. We introduce a driven lattice-gas model to study the effects of motor-induced depolymerization on the length of active biopolymers and find that increasing motor activity sharpens unimodal steady-state length distributions. Furthermore, for sufficiently fast moving motors, the relative width of the length distribution is determined only by the attachment rate of motors. Our results show how established molecular processes can be used to robustly regulate the size of cytoskeletal structures like mitotic spindles.
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