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  • Title: Sesquiterpenoids from the mangrove-derived endophytic fungus Diaporthe sp.
    Author: Zang le Y, Wei W, Guo Y, Wang T, Jiao RH, Ng SW, Tan RX, Ge HM.
    Journal: J Nat Prod; 2012 Oct 26; 75(10):1744-9. PubMed ID: 23006147.
    Abstract:
    A new sesquiterpenoid, diaporol A (1), possessing a unique tricyclic lactone framework, eight new drimane sesquiterpenoids, diaporols B-I (2-9), and the known compounds 10 and 11 were isolated from a culture of the mangrove-derived endophyte Diaporthe sp. The absolute configurations of 1-5 were determined by low-temperature (100 K) single-crystal X-ray diffraction with Cu Kα radiation. The compounds were evaluated for cytotoxic activity; however, no compound showed significant cytotoxicity against the tested cell lines at a concentration of 20 μM.
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