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  • Title: Structure-activity relationships of bergenin derivatives effect on α-glucosidase inhibition.
    Author: Kashima Y, Yamaki H, Suzuki T, Miyazawa M.
    Journal: J Enzyme Inhib Med Chem; 2013 Dec; 28(6):1162-70. PubMed ID: 23009660.
    Abstract:
    The α-glucosidase inhibitory activities of bergenin derivatives were evaluated. Bergenin derivatives were synthesized from bergenin which is a characteristic compound of B. ligulata. A new bergenin derivative, 11-O-(3',4'-dimethoxybenzoyl)-bergenin showed the highest potent inhibitory activity among those of bergenin derivatives. The presence of substituents at 3',4'-position in bergenin derivatives altered the α-glucosidase inhibitory activity. 11-O-(3',4'-dimethoxybenzoyl)-bergenin was noncompetitive inhibitor for α-glucosidase. The present study reveals that bergenin derivatives could be classified as a new group of α-glucosidase inhibitors.
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