These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis, characterization and biological screening of sulfonamides derived form 2-phenylethylamine.
    Author: Rehman AU, Afroz S, Abbasi MA, Tanveer W, Khan KM, Ashraf M, Ahmad I, Afzal I, Ambreen N.
    Journal: Pak J Pharm Sci; 2012 Oct; 25(4):809-14. PubMed ID: 23009998.
    Abstract:
    In the present study, a series of N-substituted derivatives of 2-phenylethylamine has been synthesized. The reaction of 2-phenylethylamine (1) with benzene sulfonyl chloride (2) yielded N-(2-phenylethyl) benzenesulfonamide (3), which further on treatment with alkyl/acyl halides (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i). These derivatives were characterized by IR, (1)H-NMR and EI-MS and then screened against acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase enzyme (LOX) and were found to be potent inhibitors of butyryl cholinesterase only.
    [Abstract] [Full Text] [Related] [New Search]