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  • Title: Characterization of carotid plaques on 3-dimensional ultrasound imaging by registration with multicontrast magnetic resonance imaging.
    Author: Chiu B, Shamdasani V, Entrekin R, Yuan C, Kerwin WS.
    Journal: J Ultrasound Med; 2012 Oct; 31(10):1567-80. PubMed ID: 23011620.
    Abstract:
    OBJECTIVES: The ability of magnetic resonance imaging (MRI) in carotid plaque component identification has been well established. However, compared to the costly nature of MRI, 3-dimensional (3D) ultrasound imaging is a more cost-effective assessment tool. Thus, an attractive alternative for carotid disease monitoring would be to establish a strategy in which 3D ultrasound imaging is used as a screening tool that precedes MRI. To develop and validate such a protocol, registration between ultrasound and MR images is required. This article introduces a surface-based algorithm for efficient ultrasound imaging-MRI registration. METHODS: A surface-based 3D iterative closest point registration method was developed to align surfaces reconstructed from outer wall boundaries segmented from 3D ultrasound and MR images. The 3D ultrasound image was transformed according to the registration result and resliced to match corresponding 2-dimensional transverse MR images. Although rigid iterative closest point registration was used, the cross-sectional ultrasound images produced by the reslicing procedure can be moved relative to the MR images by an expert observer using in-house software, making nonrigid registration possible. RESULTS: We evaluated the registration accuracy associated with the algorithm using a vascular phantom as well as in vivo ultrasound and MR images. Our registration method was shown to have an average error of 0.3 mm in the phantom study and less than 1 mm in the in vivo study. Our findings in terms of the average intensity of each component are consistent with histologically validated results described in previous ultrasound characterization studies. CONCLUSIONS: We have developed a surface-based algorithm capable of registering ultrasound and MR images with high accuracy. This registration tool will potentially play an important role in a cost-effective screening protocol in which ultrasound is used to identify patients with a suspicion of vulnerable plaques, who are then further studied with MRI.
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