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  • Title: A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy.
    Author: Xiao H, Yan L, Zhang Y, Qi R, Li W, Wang R, Liu S, Huang Y, Li Y, Jing X.
    Journal: Chem Commun (Camb); 2012 Nov 11; 48(87):10730-2. PubMed ID: 23012698.
    Abstract:
    A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.
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