These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cold hardening modulates K+ homeostasis in the brain of Drosophila melanogaster during chill coma.
    Author: Armstrong GA, Rodríguez EC, Meldrum Robertson R.
    Journal: J Insect Physiol; 2012 Nov; 58(11):1511-6. PubMed ID: 23017334.
    Abstract:
    Environmental temperature is one of the most important abiotic factors affecting insect behaviour; virtually all physiological processes, including those which regulate nervous system function, are affected. At both low and high temperature extremes insects enter a coma during which individuals do not display behaviour and are unresponsive to stimulation. We investigated neurophysiological correlates of chill and hyperthermic coma in Drosophila melanogaster. Coma resulting from anoxia causes a profound loss of K(+) homeostasis characterized by a surge in extracellular K(+) concentration ([K(+)](o)) in the brain. We recorded [K(+)](o) in the brain during exposure to both low and high temperatures and observed a similar surge in [K(+)](o) which recovered to baseline concentrations following return to room temperature. We also found that rapid cold hardening (RCH) using a cold pretreatment (4°C for 2h; 2h recovery at room temperature) increased the peak brain [K(+)](o) reached during a subsequent chill coma and increased the rates of accumulation and clearance of [K(+)](o). We conclude that RCH preserves K(+) homeostasis in the fly brain during exposure to cold by reducing the temperature sensitivity of the rates of homeostatic processes.
    [Abstract] [Full Text] [Related] [New Search]