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  • Title: [Adjuvant chemotherapy of osteosarcoma].
    Author: Yamawaki S, Isu K, Ubayama Y, Takeda N, Yagi T, Usui M, Isii S.
    Journal: Gan To Kagaku Ryoho; 1990 Feb; 17(2):180-8. PubMed ID: 2301948.
    Abstract:
    Osteosarcoma is the one of the tumors that's prognosis have been improved dramatically by the introduction of chemotherapy consisting mainly of adriamycin, high-dose methotrexate with Leucovorin rescue and cisplatinum. Now, the purpose of the treatment for osteosarcoma are assurance of their life and functional and beautiful limb-sparing. Recently, preoperative chemotherapy for limb saving is given to patients with osteosarcoma of the extremities. The five year survival rate increased to 65% and limb sparing rate became above 50%. It is generally accepted that pre- and post-operative chemotherapy can inhibit pulmonary micro metastasis and prove to be of great significance in improving the survival rate of patients with osteosarcoma of extremities and achieve limb salvage operation.
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