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  • Title: Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia.
    Author: Nakahara N, Fujise N, Kawanishi G, Mizobe F.
    Journal: Brain Res; 1990 Jan 15; 507(1):172-5. PubMed ID: 2302575.
    Abstract:
    Effects of FKS-508 (AF102B; cis-2-methylspiro (1,3-oxathiolane-5,3')-quinuclidine), a novel M1-selective agonist, on central muscarinic responses in mice were examined in comparison with oxotremorine. FKS-508 was slightly less potent (6 times) in reversal of scopolamine-induced amnesia (passive avoidance failure), but far less potent (260 and 55 times) in producing hypothermia and tremor than oxotremorine. These results show that the selective M1 agonist FKS-508 differentiates highly between the central muscarinic effects.
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