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  • Title: A new automated NaCl based robust method for routine production of gallium-68 labeled peptides.
    Author: Schultz MK, Mueller D, Baum RP, Leonard Watkins G, Breeman WA.
    Journal: Appl Radiat Isot; 2013 Jun; 76():46-54. PubMed ID: 23026223.
    Abstract:
    A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (<15 min) and removal of organic solvents. The method produces high peptide-bound % (>97%), and specific activity (>40 MBq nmole(-1) [(68)Ga]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals.
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