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  • Title: Atenolol to treat intestinal ischemia and reperfusion in rats.
    Author: Campos VF, Miranda-Ferreira R, Taha NS, Teixeira GD, Souza WT, Carmo CE, Silva-Neto LA, Gomes IT, Monteiro HP, Montero EF, Fagundes DJ, Caricati-Neto A, Taha MO.
    Journal: Transplant Proc; 2012 Oct; 44(8):2313-6. PubMed ID: 23026582.
    Abstract:
    To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with AT (1.5 mg · kg(-1), intravenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy analysis. Compared to the sham group, jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.
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