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  • Title: Complexity of β-lactamases among clinical Aeromonas isolates and its clinical implications.
    Author: Chen PL, Ko WC, Wu CJ.
    Journal: J Microbiol Immunol Infect; 2012 Dec; 45(6):398-403. PubMed ID: 23031536.
    Abstract:
    Aeromonas species, aquatic Gram-negative bacilli, distributed globally and ubiquitously in the natural environment, may be implicated in a variety of human diseases. They can produce various β-lactamases which confer resistance to a broad spectrum of β-lactams, and therefore in vitro susceptibility testing must be used to guide antimicrobial therapy. However, conventional in vitro susceptibility tests may sometimes fail to detect these β-lactamases, and hence raise a therapeutic challenge. In this review article, two chromosomally mediated β-lactamases (i.e., AmpC β-lactamases and metallo-β-lactamases) and acquired extended-spectrum β-lactamases in aeromonads are reviewed, and the clinical implications of the complexity of β-lactamases are discussed.
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