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  • Title: A new paradigm in viral resistance.
    Author: Ruiz A, Russell SJ.
    Journal: Cell Res; 2012 Nov; 22(11):1515-7. PubMed ID: 23033124.
    Abstract:
    The rapid mutation of RNA viruses allows for the acquisition of resistance to drugs directly targeting viral proteins. Therefore, a novel approach to the development of antivirals centers on targeting host factors critical to viral replication. A recent report has brought to light the potential for RNA viruses to also develop resistance against compounds targeting crucial host factors, suggesting that a combination of drugs with various targets may be necessary for preventing resistance.
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